A Medication for Dissociation? (Healing DID)
(Summary) Many people are surprised to learn that researchers are exploring whether a certain medication—initially developed for an entirely different purpose—might help reduce the numbing or “fogged out” side of dissociation. Early studies focus on depersonalization and derealization, not DID, but the findings raise important questions about what dissociation is, how the brain protects itself, and what might support healing. This post breaks down what the research actually shows, what it doesn’t, and how to make sense of medication as a possible adjunct—not a replacement—for trauma-informed care.
Did you know a medication originally used to treat addiction is now being studied for dissociation?
The research so far is small but interesting. A few studies on depersonalization and derealization found that naltrexone sometimes reduces the sense of emotional numbness or unreality. The idea is that it gently blocks part of the brain’s opioid system, which can become over-activated during trauma responses that cause detachment.
It’s important to understand what this means—and what it doesn’t.
The evidence mainly involves depersonalization and derealization disorder, not DID. In DID, dissociation can include amnesia, switching, or internal separation between parts—things naltrexone hasn’t been shown to address directly. That distinction matters, because people often hear ‘dissociation’ and assume it’s all the same.
In theory, it could help with the numbing side of dissociation—those freeze or fog states—by lowering the brain’s drive to shut down. But it’s unlikely to change the structure of the system itself. So the value for people who have DID is that naltrexone could reduce some dissociative symptoms, but not all.
Because the research is still early, naltrexone is considered experimental for dissociation. When prescribed for dissociation, it’s considered an “off-label” use. It’s not a substitute for trauma-informed therapy, parts work, or stabilization for people who have DID. I’ve put a link in the description to a meta-analysis of studies investigating naltrexone for use in dissociation.
If you’re curious about it, bring it up with a psychiatrist who knows trauma and dissociation. They can help you decide whether a monitored trial makes sense for you and explain the risks and side effects.
The takeaway: naltrexone may someday become a helpful adjunct, but for now, the core of healing DID is still safety, self-understanding, and connection.
For more information about the research: https://pmc.ncbi.nlm.nih.gov/articles/PMC10591526/
Frequently Asked Questions
What is naltrexone?
Naltrexone is a medication originally developed to treat alcohol and opioid addiction. It works by blocking certain opioid receptors in the brain, which can reduce cravings and dull the brain’s natural “numbing” response.
How might naltrexone help with dissociation?
Some small studies suggest it may lessen emotional numbing or the sense of unreality seen in depersonalization and derealization. The idea is that it gently limits the brain’s tendency to shut down during stress.
Does naltrexone treat DID directly?
No. Naltrexone hasn’t been shown to affect switching, amnesia, or system structure. Its potential benefit for people with DID lies mainly in easing some symptoms of dissociation—like fog, spacing out, or emotional flatness—not in changing the condition itself.
Is naltrexone approved for dissociation?
Not yet. It’s considered “off-label,” meaning doctors may prescribe it based on clinical judgment, but it isn’t FDA-approved for dissociative disorders. Research so far is promising but limited.
What are possible side effects?
Common ones can include nausea, fatigue, headache, or mild sleep disruption. Because everyone responds differently, it’s essential to discuss risks and interactions with a licensed prescriber before trying it.
Can naltrexone replace therapy or parts work?
No. Medication can support stabilization but doesn’t replace trauma-informed therapy, parts communication, or building internal safety. It may make therapy easier by reducing overwhelm, but it’s only one piece of healing.
Who should I talk to if I want to learn more?
A psychiatrist experienced with trauma and dissociation is best positioned to evaluate whether a monitored trial makes sense for you. Bring any research articles or questions to discuss during your appointment.
What’s the main takeaway?
Naltrexone may someday become a helpful adjunct for dissociative symptoms, but it’s not a cure. The core of DID recovery still rests on safety, self-understanding, connection, and consistent therapeutic support.